Study on the content changes of four volatile components in Curcumae Rhizoma with different proportions of Astragali Radix and Curcumae Rhi-zoma
Objective:To investigate the changes in the content of anti-tumor active ingredients in the volatile oil of Curcumae Rhizoma in different compatibility ratios of Astragali Radix and Curcumae Rhi-zoma.Methods:Gas chromatography was used to determine the contents of β-elemene,curcuman alcohol,gemarone and neocaridione in single Curcumae Rhizoma,Astragali Radix and Curcumae Rhizoma in the compatibility ratios of 1∶1,2:1,3:1,5:1,1:2.HP-5 gas chromatography column was used with programmed warming method,and the inlet temperature was 250℃.The temperature of the FID detector is 280℃.The sample size was 1 μL,and the standard internal substance was methyl salicylate.Results:The four volatile oils of β-olive,curcumin,gemarone and neocaridione were 0.0030-0.1920 mg·mL-1(r=0.9969),0.0233-2.9790 mg·mL-1(r=0.9993),0.0059-0.3760 mg·mL-1(r=0.9994)and 0.0175,respectively.The range of-1.1180 mg·mL-1(r=0.9943)showed a good linear relationship.When Astragali Radix and Curcumae Rhi-zoma were mixed at a 2∶1 ratio,the dissolution amount of each component was the highest.Conclusions:With the different compatibility ratios of Astragali Radix and Curcumae Rhizoma,the content of antitumor members in volatile oil has changed,and the compatibility ratio of 2∶1 and 3∶1 is the best,which provides the basis for clinical application and pharmacodynamics research.
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