Effects of Exenatide on Hepatic Insulin Resistance in T2DM Patients and db/db Mice
Objective:To investigate the effects of exenatide on hepatic insulin resistance(IR),which provides a strong basis for the treatment of hepatic insulin resistance in type 2 diabetes mellitus(T2DM).Methods:A total of 80 patients with T2DM that were treated with exenatide for 6 months from August 2017 to August 2020 were enrolled.Glycosylated hemoglobin(HbA1c)and fasting blood glucose(FPG)were measured before and after treatment,moreover,body mass index(BMI),homeostatic model insulin re-sistance index(HOMA-IR)and homeostatic model islet function(HOMA-β)were calculated.The db/db mice were treated with exenatide for 8 weeks,OGTT andi ITT experiments were performed,and then fasting blood glucose and insulin levels were determined,liver sections were stained with HE and PAS.Results:After treatment of exenatide,the levels of HbA1c,FPG and HOMA-IR were significantly decreased in T2DM(P＜0.05).Exenatide increased glucose consumption in IR model of HepG2 cells(P＜0.05);Exe-natide decreased fasting blood glucose,fasting serum insulin(FINS)and HOMA-IR in db/db mice,in-creased insulin sensitivity index(ISI)and liver glycogen accumulation area(P＜0.05).Conclusion:Exe-natide improves hepatic insulin resistance.
Type 2 diabetes mellitusInsulin resistanceExenatide
万方数据
维普
