Intrahepatic cholestasis of pregnancy(ICP)frequently manifests in late pregnancy,significantly impacts the well-being of both mothers and infants.Its etiology andi pathogenesis remain unclear.The diagnosis of ICP primarily relies on serum bile acid levels.Intestinal flora significantly contributes to the synthesis and metabolism of bile acids,and both intestinal flora and its metabolites are closely associated with ICP.Microbiological interventions,including probiotic usage,can enhance the intestinal flora,presenting a novel approach for ICP treatment.In this paper,we reviewed the association between bile acid alterations and intestinal flora in ICP patients,analyzed the correlation between intestinal flora and ICP development,and found that specific bacterial strains(e.g.,Escherichia/Shigella,Bacteroides,Bifidobacterium and Lactobacillus)closely linked to ICP development.Additionally,we summarized the advancements in research on probiotic utilization to ameliorate the cholestatic process,aming to enhance comprehension of ICP and offer fresh perspectives for its clinical treatment and management.
关键词
妊娠期肝内胆汁淤积症/肠道菌群/益生菌/研究进展
Key words
Intrahepatic cholestasis of pregnancy/Intestinal flora/Probiotics/Research progress
维普
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