摘要
具有抗胆碱活性的药物(MACs)广泛应用于临床,此类药物普遍存在不良反应累加的风险,尤其在老年人群及部分特殊人群中可造成认知损害、跌倒、心血管事件、全因死亡率上升等临床不良后果.目前,国外研究者通过平均日剂量法、累加剂量法、累加抗胆碱能负担法等计算方法实现了对MACs潜在风险的具体量化,为MACs的用药评估及干预工作提供了循证性依据.本文总结了近年来MACs风险评估及用药干预的进展,为本国MACs在老年人群及特殊人群的安全使用提供参考.
Abstract
Medications with anticholinergic activity(MACs)are broadly used in general population,such drugs are supposed to generate accumulated risk of adverse drug reactions(ADRs),including cognitive impairments,falls,cardiovascular events,long-term all-cause mortality,etc.,especially in the elderly people.Currently,risk quantification of MACs is achieved by calculation methods such as average daily dose,cumulative dose measure and cumulative anticholinergic burden by foreign researchers so as to provide evidence-based norms to MACs-related pharmaceutical intervention.This article summarizes the advance of MACs risk evaluation and intervention,so as to provide reference for the drug safety in the elderly and special patient populations domestically.
维普
万方数据