Efficacy and Safety of Colistin Sulfate Combined Therapy for Extensively Drug Resistant Gram-negative Bacteria Infection in ICU
Objective:To evaluate the efficacy and safety of colistin sulfate in the treatment of exten-sively drug resistant(XDR)gram-negative bacteria infection in ICU.Methods:For patients with XDR gram-negative bacteria infection treated with colistin sulfate in the ICU of our hospital,the target pathogen,combined drug regimen,administration method and dose were collected,and their efficacy and adverse re-actions were observed and evaluated.Results:A total of 109 patients were treated with colistin sulfate combined anti infection,68 cases(62.4％)were clinically effective;65 cases(59.6％)were bacteriologically clearance;and 3 cases(2.8％)of adverse reactions of kidney injury,1 case was probably,2 cases were possibly.Conclusions:For severe patients with XDR gram-negative bacteria infection,the combined anti infection regimen containing colistin sulfate has good efficacy and high safety,but it is still necessary to pay attention to the possible adverse reactions of renal injury.
Colistin sulfateCombined anti infection regimenExtensively drug resistant gram-negative bacteriaEfficacySafety
万方数据
维普
