药学与临床研究2024,Vol.32Issue(2) :169-171.

1例泛耐药肺炎克雷伯菌尿源性脓毒症伴血小板减少的给药策略分析

Dosing Strategy Analysis of a Case of Pan-resistant Klebsiella Pneumoniae Urinogenic Sepsis with Thrombocytopenia

杨娟艳 高岸 徐红冰
药学与临床研究2024,Vol.32Issue(2) :169-171.

1例泛耐药肺炎克雷伯菌尿源性脓毒症伴血小板减少的给药策略分析

Dosing Strategy Analysis of a Case of Pan-resistant Klebsiella Pneumoniae Urinogenic Sepsis with Thrombocytopenia

杨娟艳 1高岸 2徐红冰2
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作者信息

  • 1. 上海交通大学医学院附属第一人民医院临床药学科,上海 200080;印江土家族苗族自治县中医医院药剂科,贵州铜仁 555200
  • 2. 上海交通大学医学院附属第一人民医院临床药学科,上海 200080
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摘要

临床药师对1例泛耐药肺炎克雷伯菌尿源性脓毒症伴血小板减少患者进行用药干预,分析替加环素联合黏菌素治疗效果不佳及血小板减少的原因,推荐头孢他啶阿维巴坦单药治疗产肺炎克雷伯菌(KPC)碳青霉烯酶类耐药肺炎克雷伯菌(CRKP)的重症感染,基于患者感染部位、病原菌酶型等,制定抗感染治疗方案后,患者感染指标和血小板逐渐恢复至正常范围,病情好转.

Abstract

Clinical pharmacists performed medication intervention in a patient with pan-resistant Kleb-siella pneumoniae urinogenic sepsis with thrombocytopenia,analyzed the poor treatment effects of tigecycline combined with colistin and the causes of thrombocytopenia and recommended ceftazidime/avibactam for se-vere infections by KPC enzymes producing carbapenem-resistant Klebsiella pneumonia(CRKP).Based on the site of infection type of pathogen enzyme,clinical pharmacists developed an anti-infection treatment plan,the infection index and platelets gradually recovered to normal ranges.By working with the clinical treatment team,the infection symptoms were controlled with conditions improved.

关键词

泛耐药肺炎克雷伯菌/尿源性脓毒症/头孢他啶/阿维巴坦/血小板减少

Key words

Extensive drug-resistant Klebsiella pneumoniae/Urinary sepsis/Ceftazidime/avibactam/Platelet reduction

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出版年

2024
药学与临床研究
江苏省药学会

药学与临床研究

CSTPCD
影响因子:0.95
ISSN:1673-7806
参考文献量12
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