Analysis of 30 Cases of Drug Reaction with Eosinophilia and Systemic Symptoms
Objective:To assess the onset time characteristics of drug reaction with eosinophilia and systemic symptoms(DRESS)in children after drug exposure and the types of suspected allergenic drugs.Method:Retrospect the characteristics of pediatric cases diagnosed with DRESS in our hospital over the past decade.According to the occurrence time of DRESS,the retrospected cases were divided into two groups:the rapid onset group(＜15 days)and the delayed onset group(＞15 days).Results:Among the 30 pediatric patients,17 were in the rapid onset group(＜15 days),and 13 were in the delayed onset group(≥ 15 days).The average onset time of DRESS is(11.13±8.69)days,which is less than 15 days.After culprit drug withdrawal,the average duration of DRESS was(22.80±19.65)days.Antibiotics account for 43.3％of allergenic drugs,with the majority being in the rapid onset group.Antiepileptic drugs accounted for 32.3％,with 6 cases in the delayed onset group.Conclusion:DRESS mostly occurs within 15 days af-ter suspected drug exposure,and can also occur more than 15 days after suspected drug exposure.There was no difference between the two groups.The study also found that the main sensitizing drugs for chil-dren's drug hypersensitivity reactions are antibiotics and antiepileptic drugs.
Drug reaction with eosinophilia and systemic symptomsClinical analysisChild
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