Mechanism and Research Progress of PD-1/PD-L1 Inhibitors Caused Vitiligo Like Discoloration in the Treatment of Malignant Melanoma
In recent years,more and more tumor patients treated with immune checkpoint inhibitors(ICPIs)showed significant effects.Among them,programmed cell death-1/ligand-1(PD-1/PD-L1)inhibitors are second-generation ICPIs,which have been approved for the treatment of various advanced malignant tumors.With their widespread use,immune-related adverse events(irAEs)have gradually attracted people's attention and vitiligo is one of them,especially in the treatment of patients with malignant melanoma.This article will review the mechanism of vitiligo like discoloration caused by the use of PD-1/PD-L1 immunosuppressants in patients with malignant melanoma,aiming to provide a possible theoretical basis for clarifying the relationship between PD-1/PD-L1 and immune-related adverse reactions.
Programmed death-1/programmed cell death ligand 1Immunosuppressive agentsMalignant melanomaVitiligo like discolorationPathogenesis
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