Clinical Efficacy and Influencing Factors of Oral Minocycline in the Treat-ment of Carbapenem-resistant Acinetobacter baumannii Infection
Objective:To evaluate clinical efficacy of minocycline in the treatment of Carbapenem-re-sistant Acinetobacter baumannii(CRAB)infection,and analyze the related influencing factors.Methods:Clinical data of patients who were treated with minocycline orally in the General Hospital of Eastern The-ater Command from June 2023 to October 2023 was retrospectively collected,and the influencing factors of clinical efficacy were analyzed by logistic regression.Results:Eighty-three patients with confirmed or sus-pected CRAB infection and treated with minocycline orally were finally included.The clinical efficacy rate was 54.22％and the microbiological clearance rate was 49.40％.Logistic regression analysis showed that the minimum inhibitory concentration(MIC)of minocycline for CRAB ≥ 16 mg·L-1 was an independent risk factor for clinical efficacy and microbiological clearance(OR 0.08,95％CI 0.01-0.44,P=0.004;OR 0.10,95％CI 0.02-0.51,P=0.006).In addition,length of hospitalization＞30 days was an independent risk fac-tor for microbiologic clearance(OR 0.34,95％CI 0.12-0.97,P=0.043;OR 0.08,95％CI 0.01-0.42,P=0.003).Conclusion:The study based on small sample size in a single center shows that clinical efficacy of oral minocycline in the treatment of patients with CRAB infection is limited.When the MIC of minocy-cline for CRAB is greater than or equal to 16mg·L-1,anti-infective clinical efficacy and microbiological clearance are significantly reduced.
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