Impact of Ferroptosis on Alzheimer's Disease and Its Drug Research Progress
Alzheimer's disease(AD)is a chronic degenerative condition affecting the central nervous system and is the most prevalent form of senile dementia.Unfortunately,it remains incurable at present.In recent years,a novel iron-dependent form of cell death called ferroptosis has been identified.This process is characterized by an excess of iron accumulation,inactivation of glutathione peroxidase 4,and elevated levels of reactive oxygen species and lipid peroxides.Recent evidence indicates that ferroptosis plays an important role in the pathological process of AD,but its specific mechanism is still unclear.This article reviews the potential interactions of iron imbalance leading to senile plaque and neurofibrillary tangles,aggravating neuroinflammation,and mediating neuronal cell death.In addition,this article summarizes the AD treatment strategies related to ferroptosis,such as iron chelators,antioxidants and ferroptosis regulators,to provide valuable information for the diagnosis and treatment of AD in the future.
NETL
NSTL
万方数据
