Porous microspheres,as a novel drug delivery system,have been extensively studied in the field of drug delivery.The application of emerging techniques such as membrane emulsification and super-critical fluid technology not only improves the uniformity of particle size but also overcomes the potential problems such as solvent residue existing in traditional preparation methods.In addition,porous micro-spheres adsorb and encapsulate drugs by physical or chemical forces,and post-adsorption techniques such as heating,infrared radiation,and temperature rise,infrared radiation,and solvent induction can be em-ployed to close the pores after adsorption to improve the encapsulation efficiency of drugs and overcome the drug burst release.In this paper,we summarize the mechanisms and characteristics of various prepara-tion methods and the drug adsorption methods of porous microspheres,and its application progress in drug delivery.
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