首页|Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation

Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation

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Background:To investigate the effect of intra-abdominal volume increment (IAVI) on intra-abdominal hypertension (IAH) in the kidneys.Methods:Eight minipigs were successfully established as IAH models and were randomly divided into two groups:the IAVI group and the sham-operated group.The intravesical pressure,inferior vena cava pressure and urine volume were measured before shock,2 h after IAH,and 22 h after surgery,respectively.The following indices were measured:serum creatinine,urea nitrogen,renal cortical thickness,ratio of abdominal anteroposterior diameter/transverse diameter,renal thickness,diameter of the renal sinus and the wet/dry ratio of renal tissues.Results:The intravesical pressure (IVP) of the 8 minipig IAH models was calculated to be 21.16±4.63 mmHg.There was a significant increase in the abdominal anteroposterior diameter/transverse diameter ratio.The minipigs in the IAVI group survived during the observational period,whereas 2 minipigs died at 18 h and 20 h in the sham-operated group.Twenty-two hours after surgery,the animals in the IAVI group displayed increased urinary volume (UV) and decreased Cr and Ur and remarkable decreases of VP and IVCP.After IAH,the renal cortical thickness and the renal thickness increased significantly.The renal wet/dry ratio in the sham-operated group was higher than that in the IAVI group.Conclusion:IAVI helps to control renal dysfunction after IAH,which may be related to lowering the intra-abdominal pressure,thus alleviating renal edema and blood stasis.

intra-abdominal volume incrementintra-abdominal hypertensiontraumashockresuscitation

Zheng-Gang Wang、Hao Tan、Lian-Yang Zhang、Dao-Cheng Liu、Hua-Liang Xiao、Wen-Hua Du

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State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing 400042, China

authors acknowledge support,in part,from the "Twelfth Five-Year Plan" Scientific and Technological Supporting Program of ChiChongqing integrated demonstration project

2012BAI11B00cstc2013jcsfC10001

2014

10.1186/2054-9369-1-4

军事医学研究(英文)

军事医学研究(英文)

ISSN：2095-7467
年,卷(期)：2014.1(1)
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