首页|Regeneration of the heart:from molecular mechanisms to clinical therapeutics

Regeneration of the heart:from molecular mechanisms to clinical therapeutics

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Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

Heart regenerationCardiac diseaseTherapeuticsSignaling mechanisms

Qian-Yun Guo、Jia-Qi Yang、Xun-Xun Feng、Yu-Jie Zhou

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Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease,Beijing Institute of Heart Lung and Blood Vessel Disease,Clinical Center for Coronary Heart Disease,Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China

Natural Science Foundation of Beijing,ChinaNatural Science Foundation of Beijing,ChinaBeijing Hospitals Authority Youth ProgrammeChinese Scholarship Council(CSC)scholarshipNational Key Research and Development Program of ChinaBeijing Municipal Health CommissionBeijing Municipal Health CommissionNational Natural Science Foundation of China

72142237212027QML202106012017062104152017YFC0908800PXM2020_026272_000002PXM2020_026272_00001482070293

2024

10.1186/s40779-023-00452-0

军事医学研究(英文)

军事医学研究(英文)

CSTPCD
ISSN：2095-7467
年,卷(期)：2024.11(1)
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