首页|Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis

Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis

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Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life quality.Consequently,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA.Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging.Herein,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.

Rheumatoid arthritisFluorescent probeImagingDiagnosisBiomarker

Pan Luo、Fu-Qiang Gao、Wei Sun、Jun-You Li、Cheng Wang、Qing-Yu Zhang、Zhi-Zhuo Li、Peng Xu

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Department of Joint Surgery,Honghui Hospital,Xi'an Jiaotong University,Xi'an 710054,China

Department of Orthopedics,China-Japan Friendship Hospital,Beijing 100029,China

Department of Orthopaedic Surgery of the Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA

School of Mechanical Engineering,Sungkyunkwan University,Suwon 16419,South Korea

Department of Orthopaedic Surgery,Peking University Third Hospital,Peking University,Beijing 100191,China

Department of Orthopedics,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China

State Key Laboratory of Pharmaceutical Biotechnology,Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China

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National Natural Science Foundation of ChinaChina-Japan Friendship Hospital Horizontal Project/Spontaneous Research FundingNational High Level Hospital Clinical Research FundingElite Medical Professionals project of China-Japan Friendship Hospital

820724322022-HX-JC-72022-NHLHCRF-PY-20ZRJY2021-GG12

2024

10.1186/s40779-023-00467-7

军事医学研究(英文)

军事医学研究(英文)

CSTPCD
ISSN：2095-7467
年,卷(期)：2024.11(2)
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