首页|Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,oppor tunities and challenges

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,oppor tunities and challenges

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Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound repair.As a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy.Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair follicles.In addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and anti-fibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix production.Additionally,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma repair.Through the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair.In conclusion,MSC-derived EV-based therapies have important application prospects in wound repair.Here we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

Mesenchymal stem cell(MSC)Extracellular vesicles(EVs)Wound repairEngineered nanoparticles

Jia-Yi Ding、Min-Jiang Chen、Ling-Feng Wu、Gao-Feng Shu、Shi-Ji Fang、Zhao-Yu Li、Xu-Ran Chu、Xiao-Kun Li、Zhou-Guang Wang、Jian-Song Ji

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Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,Institute of Imaging Diagnosis and Minimally Invasive Intervention Research,the Fifth Affiliated Hospital of Wenzhou Medical University,Zhejiang,Lishui 323000,China

Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou 325035,Zhejiang,China

Clinical College of the Affiliated Central Hospital,School of Medicine,Lishui University,Lishui 323000,Zhejiang,China

Department of Overseas Education College,Jimei University,Xiamen 361021,Fujian,China

Department of Medicine II,Internal Medicine,Cardio-Pulmonary Institute(CPI),Universities of Giessen and Marburg Lung Center(UGMLC),Member of the German Center for Lung Research(DZL),Justus-Liebig University Giessen,35392 Giessen,Germany

Pulmonary and Critical Care,Department of Medicine V,Internal Medicine,Infectious Diseases and Infecti

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National Key Research and Development Project Intergovernmental Cooperation in Science and Technology of ChinaKey R&D Program of Lishui CityNational Natural Science Foundation of China

2018YFE01269002021ZDYF1282271629

2024

10.1186/s40779-023-00472-w

军事医学研究(英文)

军事医学研究(英文)

CSTPCD
ISSN：2095-7467
年,卷(期)：2024.11(3)
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