首页|Bioengineered skin organoids:from development to applications

Bioengineered skin organoids:from development to applications

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Signifcant advancements have been made in recent years in the development of highly sophisticated skin organoids.Serving as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional(2D)systems and ethical concerns.The inherent plasticity of skin organoids allows for their construction into physiological and pathological models,enabling the study of skin development and dynamic changes.This review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages.Furthermore,it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques,such as 3D printing and microfuidic devices.The review also summarizes and discusses the diverse applications of skin organoids in developmental biology,disease modelling,regenerative medicine,and personalized medicine,while considering their prospects and limitations.

Skin organoidOrganoid generationSkin appendageTissue engineeringDisease modellingRegenerative medicine

Zi-Xuan Hong、Shun-Tian Zhu、Hao Li、Jing-Zhi Luo、Yu Yang、Yang An、Xi Wang、Kai Wang

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Department of Physiology and Pathophysiology,School of Basic Medical Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing 100191,China

Department of Hepatopancreatobiliary Surgery,the Third Affiliated Hospital of Soochow University,Changzhou 213000,Jiangsu,China

Department of Plastic Surgery,Peking University Third Hospital,Beijing 100191,China

Clinical Stem Cell Research Center,Peking University Third Hospital,Beijing 100191,China

State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,Beijing 100037,China

Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease,Capital Medical University,Beijing 100050,China

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National Key Research and Development Program of ChinaBeijing Nova ProgramNational Natural Science Foundation of ChinaOpen Research Fund of State Key Laboratory of Cardiovascular Disease,Fuwai HospitalClinical Medicine Plus X-Young Scholars Project,Peking UniversityEmerging Engineering Interdisciplinary-Young Scholars Project,Peking UniversityFundamental Research Funds for the Central UniversitiesOpen Research Fund of State Key Laboratory of Digital Medical Engineering,Southeast UniversityOpen Research Fund of Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease,Beijing,ChinaScience and Technology Bureau Foundation Application Project of Changzhou

2022YFA110480020220484100818739392022KF-04PKU2022LCXQ003PKU2023XGK0112023K-01DXWL2023-01CJ20220118

2024

10.1186/s40779-023-00475-7

军事医学研究(英文)

军事医学研究(英文)

CSTPCD
ISSN：2095-7467
年,卷(期)：2024.11(3)
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