Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance:from regulatory mechanism to targeted therapeutic strategy

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外文摘要：Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury.However,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic target.Here,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia.Additionally,potential clinical translation prospects for targeting Drp1 are discussed.This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.

外文关键词：

Dynamin-related protein 1(Drp1)Hypoxic-ischemic injuryMitochondrial quality imbalanceCell dysfunctionOrgan damage

作者：

Shuai Hao、He Huang、Rui-Yan Ma、Xue Zeng、Chen-Yang Duan

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作者单位：

Department of Anesthesiology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China

Research Institute of General Surgery,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210002,China

Department of Cardiovascular Surgery,Xinqiao Hospital,Army Medical University,Chongqing 400037,China

Institute for Brain Science and Disease,Chongqing Medical University,Chongqing 400010,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaSenior Medical Talents Program of Chongqing for Young and MiddleagedKuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

项目编号：

8227225282270378

出版年：

2024

DOI：

10.1186/s40779-023-00482-8

军事医学研究(英文)

CSTPCD

ISSN：2095-7467

年,卷(期)：2024.11(4)