首页|Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
维普
Cancer immunotherapy using immune-checkpoint inhibitors(ICIs)has revolutionized the field of cancer treatment;however,ICI efficacy is constrained by progressive dysfunction of CD8+tumor-infiltrating lymphocytes(TILs),which is termed T cell exhaustion.This process is driven by diverse extrinsic factors across heterogeneous tumor immune microenvironment(TIME).Simultaneously,tumorigenesis entails robust reshaping of the epigenetic landscape,potentially instigating T cell exhaustion.In this review,we summarize the epigenetic mechanisms governing tumor microenvironmental cues leading to T cell exhaustion,and discuss therapeutic potential of targeting epigenetic regulators for immunotherapies.Finally,we outline conceptual and technical advances in developing potential treatment paradigms involving immunostimulatory agents and epigenetic therapies.
State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School & Hospital of Stomatology,Frontier Science Center for Immunology and Metabolism,Wuhan University,Wuhan 430079,China
Department of Oral Maxillofacial-Head Neck Oncology,School and and Hospital of Stomatology,Wuhan University,Wuhan 430079,China
万方数据
维普
