首页|Targeting NR1D1 in organ injury:challenges and prospects

Targeting NR1D1 in organ injury:challenges and prospects

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Nuclear receptor subfamily 1,group D,member 1(NR1D1,also known as REV-ERBα)belongs to the nuclear receptor(NR)family,and is a heme-binding component of the circadian clock that consolidates circadian oscillators.In addition to repressing the transcription of multiple clock genes associated with circadian rhythms,NR1D1 has a wide range of downstream target genes that are intimately involved in many physiopathological processes,including autophagy,immunity,inflammation,metabolism,and aging in multiple organs.This review focuses on the pivotal role of NR1D1 as a key transcription factor in the gene regulatory network,with particular emphasis on the milestones of the latest discoveries of NR1D1 ligands.NR1D1 is considered as a promising drug target for treating diverse diseases and may contribute to research on innovative biomarkers and therapeutic targets for organ injury-related diseases.Further research on NR1D1 ligands in prospective human trials may pave the way for their clinical application in many organ injury-related disorders.

Nuclear receptor subfamily 1group Dmember 1(NR1D1)Circadian rhythmsLiverHeartLungKidney

Zi-Yin Zhang-Sun、Xue-Zeng Xu、Germaine Escames、Wang-Rui Lei、Lin Zhao、Ya-Zhe Zhou、Ye Tian、Ya-Nan Ren、Darío Acuña-Castroviejo、Yang Yang

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Department of Cardiology,Northwest University First Hospital,Faculty of Life Sciences and Medicine,Northwest University,Xi'an 710069,China

Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,Faculty of Life Sciences and Medicine,Northwest University,Xi'an 710069,China

Department of Cardiovascular Surgery,Xijing Hospital,Air Force Medical University,Xi'an 710032,China

Biomedical Research Center,Department of Physiology,Faculty of Medicine,Institute of Biotechnology,Technological Park of Health Sciences,University of Granada,18016 Granada,Spain

Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable(CIBERFES),Ibs.Granada,San Cecilio University Hospital,18016 Granada,Spain

UGC of Clinical Laboratories,San Cecilio Clinical University Hospital,18016 Granada,Spain

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2024

10.1186/s40779-023-00495-3

军事医学研究(英文)

军事医学研究(英文)

CSTPCD
ISSN：2095-7467
年,卷(期)：2024.11(6)