摘要
目的 探讨动态血糖监测系统(CGMS)和胰岛素泵持续皮下注射治疗(CSII)在重症监护病房(ICU)2型糖尿病(T2DM)患者的应用效果.方法 将120例T2DM患者随机均分为三组:A组采用CGMS与CSII结合治疗模式(40例),B组采用单纯CSII治疗(40例),C组采用胰岛素多次注射治疗(40例).后两组采用指端毛细血糖监测法.治疗7 d后比较三组血糖控制情况、血糖达标率及血糖漂移情况.结果 治疗7 d后,A组和B组患者的全日血糖、平均血糖(MBG)、平均血糖波动幅度(MAGF)均较治疗前明显下降,且明显优于C组(P<0.05),低血糖发生次数亦较C组明显减少(P<0.05).其中,A组MBG、MAGE、低血糖次数均显著低于B组(P<0.05).结论 CGMS能监测血糖连续的变化曲线,及时发现高血糖和低血糖,与胰岛素泵联合治疗更有利于ICU糖尿病患者血糖的控制,降低低血糖的发生率.
Abstract
Objective To investigate the therapeutic outcomes of continuous glucose monitoring system(CGMS) and continuous subcutaneous insulin infusion pump system(CSⅡ) in type 2 diabetes mellitus(T2DM) patients with critical condition in intensive care unit(ICU). Methods A total of 120 T2DM patients in ICU was randomly divided into three groups with 40 cases each. CGMS combined with CSⅡ was used in group A, CSⅡ alone in group B and repeated injection of insulin therapy in group C. The capillary blood glucose of finger tip was monitored in groups of B and C. The changes of fasting blood glucose(FBG), mean amplitude of glycemic excursions (MAGE) and the number of hypoglycemia events were recorded and compared among three groups after for treatment 7 days.Results After pump therapy for 7 days, the whole day glucose, MBG and MAGE were all significantly lower in groups of A and B than those before treatment(P＜0. 05), which were lower in group A than those in group B(P＜0. 05). The mean blood glucose(MBG), mean amplitude of glucose fluctuation(MAGF) and hypoglycemia events of group A were obviously less than those in group B (P＜0.05). Conclusion CGMS can depict a continuous blood glucose curve,discover hyperglycemia or hypoglycemia events. CGMS combined with CSII is more beneficial to the glucose control in the critical T2DM patients in ICU.
NETL
NSTL
维普
万方数据