An analysis of influencing factors for carbapenem-resistant Enterobacteriaceae infectionin in patients undergoing hematopoietic stem-cell transplantation
Objective To investigate the risk factors for carbapenem-resistant Eenterobacteriaceae(CRE)bloodstream infection in the patients underwent hematopoietic stem-cell transplantation(HSCT).Methods A total of 992 blood tumor patients underwent HSCT were divided into two groups of A(with CRE bloodstream infection,17 cases)and B(without CRE bloodstream infection,975 cases).The demographic and clinical data of two groups were compared.The multivariate logistic regression model was used to analyze the risk factors for CRE bloodstream infection in the patients underwent HSCT.Results Among 992 patients underwent HSCT,CRE bloodstream infection occurred in 17 patients with the incidence rate of 1.71％.The percentages of males and the patients with concurrent pulmonary infections and renal insufficiency,and the use of carbapenem antibiotics,3/4 generation cephalosporins,macrolides,tigecycline,and daptomycin in group A were higher than those in group B(P＜0.05).The results of multivariate logistic regression analysis showed that male,concurrent pulmonary infection and renal dysfunction,use of macrolide antibiotics and tigecycline were the independent risk factors for CRE bloodstream infection in the patients underwent HSCT(P＜0.05).Conclusion CRE bloodstream infection is more likely to occur in HSCT patients with pulmonary infection and renal insufficiency and those used macrolide antibiotics and tigecycline before bloodstream infection.
万方数据
维普
