The correlation between rapid complete remission after chemotherapy and survival rate in the patients with multiple myeloma
Objective To analyze the correlation between rapid complete remission(CR)after chemotherapy and survival rate in the patients with multiple myeloma(MM).Methods The clinical data of 55 newly diagnosed MM patients received ≥ 4 courses of chemotherapy based on bortezomib and achieved CR for the first time were retrospectively analyzed.Among them,24 patients in group A had rapid CR(achieved CR after 2 courses of chemotherapy),while 31 patients in group B had no rapid CR(achieved CR after＞2 courses of chemotherapy).The progression free survival rate and overall survival rate of the two groups were compared by Kaplan-Meier survival curve.Multivariate Cox regression analysis was used to analyze the independent influencing factors for disease progression.Results The median follow-up time for groups of A and B was 16.2 and 22.9 months,respectively.Among 55 patients,9 patients(16.4％)died and 11 patients(20.0％)experienced disease progression.Kaplan-Meier survival curve analysis showed that the progression free survival rate of the patients in group A was lower than that of the patients in group B(P＜0.05),which of the patients with genetic high-risk factors was lower than that of the patients without genetic high-risk factors(P＜0.05).The results of multivariate Cox regression analysis showed that having genetic high-risk factors and obtaining rapid CR were the independent risk factors for disease progression in MM patients(P＜0.05).Conclusion The MM patients with genetic high-risk factors and rapid CR have a shorter progression free survival period after the chemotherapy based on bortezomib.
万方数据
维普
