An analysis of influencing factors of Helicobacter pylori infection in peritoneal dialysis patients
Objective To explore the influencing factors of Helicobacter pylori(Hp)infection in the patients undergoing peritoneal dialysis(PD).Methods Ninety-two PD patients were divided into two groups of A(with Hp infection,40 cases)and B(without Hp infection,52 cases)based on the results of 14C urea breath test.The general information,nutritional indicators,inflammation-related indicators and dialysis adequacy-related indicators of two groups were compared.Multivariate logistic regression analysis was used to investigate the influencing factors of Hp infection in PD patients.Results Compared with group B,the patients in group A were older and had longer dialysis age,higher levels of hsCRP,TNF-α,INF-γ,IL-6 and lower levels of Hb,Alb,24-h urine volume,24-h ultrafiltration volume,total Kt/V,Kt/V of residual kidney,total Ccr and residual kidney Ccr(P＜0.05).Multivariate logistic regression analysis showed that older age and longer dialysis age were the independent risk factors for Hp infection in PD patients,while increased Kt/V and Ccr of residual kidney were the independent protective factors for Hp infection of PD patients(P＜0.05).Conclusion PD patients are at high risk of Hp infection,and Hp infection is closely related to inflammatory response and dialysis adequacy.Anti-Hp treatment may have a positive effect on improving the prognosis of PD patients.
万方数据
维普
