Clinical efficacy of surface gastrointestinal pacing in treating gastroesophageal reflux disease
Objective To explore the clinical efficacy of surface gastrointestinal pacing in the treatment of gastroesophageal reflux disease(GERD).Methods Sixty GERD patients diagnosed through gastroscopy were randomly divided into control group and observation group with 30 cases each.Both groups were conventionally treated with esomeprazole enteric coated tablets,magnesium aluminate chewable tablets and etopride tablets.Observation group received additional surface gastrointestinal pacing therapy.The esophageal peristaltic wave parameters including lower esophageal sphincter pressure(LESP),4-second intact relaxation pressure(4sIRP),distal latency(DL),and distal contraction integral(DCI)were monitored by high-resolution esophageal manometry.The clinical symptom score,LESP and esophageal peristaltic wave parameters were recorded before and one week after treatment.Results Compared with before treatment,the total scores and scores of 7 symptoms,including heartburn,acid reflux,belching,upper abdominal pain,upper abdominal burning sensation,upper abdominal distension and chest pain were reduced and LESP,4sIRP,DL and DCI were increased in both groups after one week of treatment(P＜0.05).After one week of treatment,the total symptom score and four symptom scores of acid reflux,belching,upper abdominal distension and chest pain were lower,while LESP,4sIRP,DL and DCI were higher in observation group than those in control group(P＜0.05).After one week of treatment,the total effective rate of symptom improvement in observation group was higher than that in control group(96.7％vs.80.0％)(P＜0.05).Conclusion On the basis of conventional treatment,additionally use of surface gastrointestinal pacing therapy can more effectively improve the clinical symptoms of GERD patients.The mechanism for that may be related to enhancing the pressure of LESP and esophageal peristalsis.
万方数据
维普
