Relationship of HBV infection and ABO blood group in the population underwent hepatitis B vaccine in Qidong area
Objective To analyze the relationship of HBV infection and ABO blood group in the population underwent hepatitis B vaccine in Qidong area of Jiangsu Province.Methods A total of 12 214 subjects were randomly selected from Qidong Hepatitis B Intervention Study cohort in 2018-2020,of whom 6 595 cases(group A)accepted hepatitis B vaccine and 5 619 cases(group B)did not accept hepatitis B vaccine during neonatal period.ABO blood groups,HBsAg,HBV surface antibodies(anti-HBs)and HBV core antibodies(anti-HBc)were detected.The relationship between ABO blood groups and HBV infection was analyzed.Results In 12 214 subjects,1 122 cases were with blood type AB,3 585 cases were with blood type A,3 466 cases were with blood type B,and 4 041 cases were with blood type O.The positive rates of HBsAg and anti-HBc were lower in group A than those in group B(1.79%and 4.76%vs.7.54%and 23.88%)(P<0.01).The positive rate of HBsAg was higher in the subjects with blood type AB and A than those with blood type O in group A(2.69%and 2.30%vs.1.34%)(P<0.05).Compared with the subjects with blood type O,the risk of HBsAg positivity was increased 1.01 fold in the subjects with blood type AB and that was increased 72%in the subjects with blood type A in group A(P<0.05).Conclusion ABO blood group is related to the HBV infection in the population underwent hepatitis B vaccine in Qidong area of Jiangsu Province.The risk of HBV infection is higher in the population with blood type AB and A than that in those with blood type O.
ABO blood groupHepatitis B vaccineHepatitis B virus infection