首页|江苏启东地区乙型肝炎疫苗接种人群HBV感染与ABO血型的关系

江苏启东地区乙型肝炎疫苗接种人群HBV感染与ABO血型的关系

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目的 分析江苏启东地区乙型肝炎(乙肝)疫苗接种人群HBV感染与ABO血型的关系.方法 2018-2020年随机抽取江苏启东市乙肝干预研究队列中的12 214例为研究对象.其中,新生儿期接种乙肝疫苗6 595例(疫苗组),未接种乙肝疫苗5 619例(对照组).检测ABO血型、HBsAg、HBV表面抗体(抗-HBs)和HBV核心抗体(抗-HBc),分析不同血型与HBV感染之间的关系.结果 12 214例中,AB型1 122例,A型3 585例,B型3 466例,O型4 041例.疫苗组HBsAg和抗-HBc阳性率分布为1.79%和4.76%,低于对照组的7.54%和23.88%(P<0.01).疫苗组中,AB型和A型血HBsAg阳性率分别为2.69%和2.30%,高于O型血的1.34%(P<0.05);与O型血比较,AB型血HBsAg阳性风险增加了1.01倍(P<0.05),A型血HBsAg阳性风险增加了72%(P<0.05).结论 江苏启东地区乙肝疫苗接种人群发生HBV感染与ABO血型有关,AB型和A型血人群发生HBV感染的风险高于O型血.
Relationship of HBV infection and ABO blood group in the population underwent hepatitis B vaccine in Qidong area
Objective To analyze the relationship of HBV infection and ABO blood group in the population underwent hepatitis B vaccine in Qidong area of Jiangsu Province.Methods A total of 12 214 subjects were randomly selected from Qidong Hepatitis B Intervention Study cohort in 2018-2020,of whom 6 595 cases(group A)accepted hepatitis B vaccine and 5 619 cases(group B)did not accept hepatitis B vaccine during neonatal period.ABO blood groups,HBsAg,HBV surface antibodies(anti-HBs)and HBV core antibodies(anti-HBc)were detected.The relationship between ABO blood groups and HBV infection was analyzed.Results In 12 214 subjects,1 122 cases were with blood type AB,3 585 cases were with blood type A,3 466 cases were with blood type B,and 4 041 cases were with blood type O.The positive rates of HBsAg and anti-HBc were lower in group A than those in group B(1.79%and 4.76%vs.7.54%and 23.88%)(P<0.01).The positive rate of HBsAg was higher in the subjects with blood type AB and A than those with blood type O in group A(2.69%and 2.30%vs.1.34%)(P<0.05).Compared with the subjects with blood type O,the risk of HBsAg positivity was increased 1.01 fold in the subjects with blood type AB and that was increased 72%in the subjects with blood type A in group A(P<0.05).Conclusion ABO blood group is related to the HBV infection in the population underwent hepatitis B vaccine in Qidong area of Jiangsu Province.The risk of HBV infection is higher in the population with blood type AB and A than that in those with blood type O.

ABO blood groupHepatitis B vaccineHepatitis B virus infection

陆玲玲、陆建华、严永锋、樊春笋、曲春枫、陈陶阳

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226200 江苏,启东市人民医院(启东肝癌防治研究所、南通大学附属启东医院)病因室

中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室

ABO血型 乙型肝炎疫苗 乙型肝炎病毒感染

国家科技重大专项

2017ZX10201201-006-002

2024

江苏医药
江苏省人民医院(南京医科大学第一附属医院)

江苏医药

影响因子:0.707
ISSN:0253-3685
年,卷(期):2024.50(2)
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