Clinical characteristics of anti-TIF1-γ antibody-associated dermatomyositis
Objective To investigate the clinical characteristics of anti-transcription intermediary factor 1-γ(TIF1-γ)antibody-related dermatomyositis(DM).Methods The clinical data of 137 patients with DM were retrospectively analyzed.The follow-up time was ≥2 years.The patients were divided into two groups of A(with positive anti-TIF1-γ antibody,23 cases)and B(with negative anti-TIF1-γ antibody,114 cases).The clinical characteristics of the two groups were compared.The influencing factors for malignancy in DM patients were analyzed.Results Compared with group B,group A had a longer duration of diagnosis,higher levels of forced vital capacity and carbon monoxide diffusing capacity,higher incidence of DM-related typical skin rash and malignancy,and lower incidence of"technician's hand"and interstitial lung disease(P＜0.05 or P＜0.01).Compared with group B,group A had lower levels of globulin,serum ferritin,lactate dehydrogenase,AST,ESR and IgA(P＜0.05 or P＜0.01).Multivariate logistic regression analysis revealed that anti-TIF1-γ antibody positivity[OR=4.301,95％CI(1.182-15.642)]and older onset age of DM[OR=1.057,95％CI(1.007-1.110)]were the independent risk factors for malignancy in DM patients(P＜0.05).Conclusion The incidence of malignancy is higher in anti-TIF1-γ antibody-associated DM patients.The recognition of typical skin rash can facilitate the early diagnosis of the disease.
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