抗转录中介因子1-γ抗体相关皮肌炎的临床特征
Clinical characteristics of anti-TIF1-γ antibody-associated dermatomyositis
杨欢欢 1严婷婷 2章鑫 3周毅骏 4王雯雯 5薛静5
作者信息
- 1. 310023 浙江,杭州市西溪医院普内科
- 2. 嘉兴市第二人民医院风湿免疫科
- 3. 宁波市第六医院风湿免疫科
- 4. 310023 浙江,杭州市西溪医院肝病二科
- 5. 浙江大学医学院附属第二医院风湿免疫科
- 折叠
摘要
目的 探讨抗转录中介因子1-γ(TIF1-γ)抗体相关皮肌炎(DM)的临床特征.方法 回顾性分析137例DM患者的临床资料,随访时间≥2年.依据是否存在抗TIF1-γ抗体分为阳性组(23例)和阴性组(114例),比较两组临床特征,分析DM患者发生恶性肿瘤的影响因素.结果 与阴性组相比,阳性组诊断时间较长,用力肺活量和一氧化碳弥散量较高,DM相关典型皮疹和恶性肿瘤发生率较高,"技工手"和间质性肺疾病发生率较低(P＜0.05或P＜0.01).与阴性组相比,阳性组球蛋白、血清铁蛋白、乳酸脱氢酶、AST、ESR和IgA水平均较低(P＜0.05或P＜0.01).多因素logistic回归分析结果显示,抗TIF1-γ抗体阳性[OR=4.301,95％CI(1.182～15.642)]和DM发病年龄较大[OR=1.057,95％CI(1.007～1.110)]是DM患者发生恶性肿瘤的独立危险因素(P＜0.05).结论 抗TIF1-γ抗体相关DM患者恶性肿瘤发生率高,对典型皮疹的识别有利于早期诊断该病.
Abstract
Objective To investigate the clinical characteristics of anti-transcription intermediary factor 1-γ(TIF1-γ)antibody-related dermatomyositis(DM).Methods The clinical data of 137 patients with DM were retrospectively analyzed.The follow-up time was ≥2 years.The patients were divided into two groups of A(with positive anti-TIF1-γ antibody,23 cases)and B(with negative anti-TIF1-γ antibody,114 cases).The clinical characteristics of the two groups were compared.The influencing factors for malignancy in DM patients were analyzed.Results Compared with group B,group A had a longer duration of diagnosis,higher levels of forced vital capacity and carbon monoxide diffusing capacity,higher incidence of DM-related typical skin rash and malignancy,and lower incidence of"technician's hand"and interstitial lung disease(P＜0.05 or P＜0.01).Compared with group B,group A had lower levels of globulin,serum ferritin,lactate dehydrogenase,AST,ESR and IgA(P＜0.05 or P＜0.01).Multivariate logistic regression analysis revealed that anti-TIF1-γ antibody positivity[OR=4.301,95％CI(1.182-15.642)]and older onset age of DM[OR=1.057,95％CI(1.007-1.110)]were the independent risk factors for malignancy in DM patients(P＜0.05).Conclusion The incidence of malignancy is higher in anti-TIF1-γ antibody-associated DM patients.The recognition of typical skin rash can facilitate the early diagnosis of the disease.
关键词
皮肌炎/抗转录中介因子1-γ抗体/恶性肿瘤/皮疹Key words
Dermatomyositis/Anti-transcription intermediary factor 1-γ antibody/Malignancy/Rash引用本文复制引用
基金项目
浙江省自然科学基金(LY22H100004)
浙江省医药卫生科技计划项目(2023KY197)
出版年
2024
NETL
NSTL
万方数据