Influence of bone marrow composition of lumbar spine on bone marrow diffusion signal intensity and ADC values in healthy adults
Objective To analyze the influence of marrow composition on the bone marrow diffusion signal intensity and apparent diffusion coefficient(ADC)values of the lumbar spine in healthy adults.Methods The upper abdominal magnetic resonance imaging was analyzed in 140 healthy adults,of whom 69 cases were male and 71 cases were female.The fat fraction of bone marrow in the lumbar 1 vertebra was measured using a two-point water-lipid separation method.The muscle-normalized signal intensity of bone marrow on DWI(mnDWI)(b=800 s/mm2)of the lumbar 1 vertebra was calculated by comparing their signal intensity with that of the adjacent erector spinae muscles.Additionally,the ADC values of the lumbar 1 vertebra were measured.The mnDWI and ADC values of lumbar 1 vertebra were compared between male and female in low-,medium-,and high-fat content groups categorized by fat fraction.The correlation of bone marrow composition with mnDWI and ADC values of the lumbar 1 vertebra was analyzed for both male and female.Results The mnDWI of the lumbar 1 vertebra was significantly higher in female than in male in the low-,medium-,and high-fat content groups(P＜0.05).In the low-fat content group,the ADC values of the lumbar 1 vertebra were significantly higher in female than those in male(P＜0.01).However,in the medium-and high-fat content groups,the difference in ADC values between male and female was not significant(P＞0.05).The mnDWI of the lumbar 1 vertebra was negatively correlated with the fat fraction in both male and female(rs=-0.36,-0.55,P＜0.01).The negative correlation between ADC values and fat fraction of the lumbar 1 vertebra was found in female(rs=-0.63,P＜0.01).Conclusion The composition of bone marrow influences the mnDWI and ADC values of the lumbar spine in healthy adults,which has a certain gender difference.
Bone marrowLumbar spineDiffusion weighted imagingFat fractionGender
NETL
NSTL
万方数据
