Objective To explore the relationship of triglyceride-glucose(TyG)index and hypertensive nephropathy in elderly patients with normal serum creatinine.Methods According to the ratio of urinary albumin to creatinine(UACR),392 elderly hypertensive patients with normal serum creatinine were divided into group A(without hypertensive nephropathy,UACR≤ 30 mg/g,163 cases)and B(with hypertensive nephropathy,UACR＞30 mg/g,229 cases).The clinical data of the patients were compared between the two groups.Multivariate logistic regression was used to analyze the risk factors for hypertensive nephropathy in elderly patients with normal serum creatinine.ROC curve was used to evaluate the value of TyG index in predicting hypertensive nephropathy.Results Compared with group A,the age was older,the course of hypertension was longer,the smoking proportion,SBP,uric acid,FBG,TG,TyG index,LAD and LVDD were higher,and LVEF was lower in group B(P＜0.05).Older age,longer course of hypertension,higher uric acid and higher TyG index were the independent risk factors for hypertensive nephropathy in elderly patients with normal serum creatinine(P＜0.05).The AUC of TyG index in predicting hypertensive nephropathy in elderly patients with normal serum creatinine was 0.763[95％CI(0.715-0.812)].When the optimal cut-off value was 8.74,the sensitivity and the specificity were 77.7％and 66.3％,respectively.Conclusion In elderly hypertensive patients with normal serum creatinine,TyG index is a risk factor for hypertensive nephropathy and has a certain predictive value for its occurrence.
NETL
NSTL
万方数据
