首页|降脂抗氧化合剂治疗冠心病合并高脂血症患者的有效性和安全性

降脂抗氧化合剂治疗冠心病合并高脂血症患者的有效性和安全性

Efficacy and safety of lipid-lowering antioxidant mixture in treating the patients with coronary heart disease and hyperlipidemia

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目的 观察降脂抗氧化合剂治疗冠心病合并高脂血症患者的有效性和安全性.方法 选取冠心病合并高脂血症患者50例随机分为A组和C组,每组25例.两组均接受现代医学规范化治疗;A组加用降脂抗氧化合剂口服,每日3次,每次10 mL,连续服药2个月.采用中医证候积分和西雅图心绞痛量表评分评估临床疗效,检测治疗前后的血脂和肝肾功能指标.结果 两组治疗后中医证候积分和TG水平均降低(P<0.05),且A组低于C组[(3.26±1.96)分vs.(6.61±1.23)分和(1.39±0.43)mmol/L vs.(1.77±0.59)mmol/L](P<0.05).两组治疗后西雅图心绞痛量表评分均升高,且A组高于C组[(77.42±3.24)分vs.(69.04±3.85)分](P<0.01).两组治疗前后血常规和肝肾功能指标差异均无统计学意义(P>0.05).结论 在现代医学规范化治疗的基础上加用降脂抗氧化合剂能改善中医证候尤其是在胸痛、胸闷、倦怠方面,降低TG水平,改善心绞痛症状及生活质量.
Objective To observe the efficacy and safety of lipid-lowering antioxidant mixture in the treatment of the patients with coronary heart disease and hyperlipidemia.Methods Fifty patients with coronary heart disease and hyperlipidemia were randomly divided into two groups of A and C with 25 cases each.The patients in the two groups received modern medical standardized treatments.Group A was treated with additional lipid-lowering antioxidant mixture 10 mL orally three times a day for two months.The clinical efficacy was evaluated with TCM syndrome score and Seattle angina scale score.The blood lipid profile and liver and kidney function indicators were detected before and after treatment.Results TCM syndrome score and serum triglyceride level after treatment were significantly decreased in both groups(P<0.05),which were lower in group A than those in group C[(3.26±1.96)points vs.(6.61±1.23)points](P<0.05).Seattle angina score after treatment was significantly increased in both groups(P<0.01),which was higher in group A than that in group C[(77.42±3.24)points vs.(69.04±3.85)points](P<0.01).There were no significant differences in blood routine and liver and kidney function indexes between before and after treatment in both groups(P>0.05).Conclusion On the basis of modern medical standardized treatments,additionally oral lipid-lowering antioxidant mixture can significantly improve TCM syndrome,especially chest pain,chest tightness and burnout,reduce serum triglyceride level,and improve angina symptoms and quality of life.

Lipid-lowering antioxidant mixtureCoronary heart diseaseHyperlipidemia

蒋超鹏、郭晨贤

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213161 江苏,常州市武进中医医院心血管病科

降脂抗氧化合剂 冠心病 高脂血症

2024

江苏医药
江苏省人民医院(南京医科大学第一附属医院)

江苏医药

影响因子:0.707
ISSN:0253-3685
年,卷(期):2024.50(2)
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