Objective To analyze the risk factors for axillary lymph node metastasis in the patients with triple-negative breast cancer and establish a prediction model for axillary lymph node metastasis.Methods The risk factors for axillary lymph node metastasis in the patients with triple-negative breast cancer were analyzed.R-studio 4.0.2 was used to draw the nomographic chart of triple-negative breast cancer lymph node metastasis.Internal validation was performed using receiver operating characteristic(ROC)curve and Bootstrap self-sampling method.Results Multivariate logistic regression analysis showed that the primary tumor diameter＞2 cm[OR=4.280,95％CI(1.058-17.283)]and intravascular carcinoma thrombus[OR=24.782,95％CI(4.705-130.530)]were the independent risk factors for axillary lymph node metastasis in triple-negative breast cancer(P＜0.05).The factors associated with lymph node metastasis clinically were used to construct a nomogram of lymph node metastasis,while the results of the model showed a C-index of 0.855,indicating its good predictive ability.The AUC value was 0.907,indicating the high accuracy in predicting the status of axillary lymph node metastasis in triple-negative breast cancer.Conclusion Primary tumor diameter and intravascular carcinoma thrombus are the independent predictors of axillary lymph node metastasis in the patients with triple-negative breast cancer.The established prediction model of axillary lymph node metastasis in the patients with triple-negative breast cancer has good predictive value,which can provide accurate evaluation for clinical selection of appropriate treatment.
Triple-negative breast cancerLymph node metastasisNomogram
NETL
NSTL
万方数据
