Objective To explore the value of α-hydroxybutyrate dehydrogenase(α-HBDH)and apolipoprotein B(ApoB)in predicting major adverse cardiovascular events(MACE)occurrence within 3 years after percutaneous coronary intervention(PCI)in acute myocardial infarction(AMI)patients with multivessel disease(MVD).Methods A total of 108 AMI patients with MVD underwent PCI were divided into groups of A(33 cases with MACE)and B(75 cases without MACE)according to 3-year follow-up results.The baseline clinical data of two groups were compared.Multivariate logistic regression was used to analyze the influencing factors for MACE occurrence after PCI in AMI patients with MVD,and ROC curve was drawn to analyze the predictive efficacy of serum levels of α-HBDH and ApoB on MACE occurrence after PCI in AMI patients with MVD.Results Serum levels of α-HBDH and ApoB in group A were higher than those in group B(P<0.05).The increased serum levels of α-HBDH and ApoB were the independent risk factors for MACE occurrence in AMI patients with MVD after PCI(P<0.05).Serum level of α-HBDH or ApoB had better predictive value for MACE occurrence after PCI in AMI patients with MVD(P<0.05).The sensitivity was higher in combination of them than α-HBDH or ApoB alone.Conclusion Serum levels of α-HBDH and ApoB can be used to predict MACE occurrence after PCI in AMI patients with MVD.