首页|血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生的预测价值

血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生的预测价值

The value of α-HBDH and ApoB in predicting MACE occurrence within 3 years after PCI in AMI patients with MVD

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目的 探讨血清α羟丁酸脱氢酶(α-HBDH)和载脂蛋白B(ApoB)水平对合并多支血管病变(MVD)的急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后3年内主要不良心血管事件(MACE)发生的预测价值.方法 合并 MVD 的AMI患者108例行PCI治疗,根据3年随访结果分为A组(发生MACE,33例)和B组(未发生MACE,75例).比较两组实验室血液指标及左心室射血分数,采用多因素logistic回归分析合并MVD的AMI患者PCI术后3年内MACE发生的影响因素,绘制ROC曲线分析血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生的预测效能.结果 A组血清α-HBDH和ApoB水平高于B组(P<0.05).血清α-HBDH和ApoB水平升高是AMI合并MVD患者PCI术后MACE发生的独立危险因素(P<0.05).血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生具有良好的预测效能(P<0.05),联合检测的灵敏度更高.结论 血清α-HBDH和ApoB水平可用于预测AMI合并MVD患者PCI术后3年内MACE的发生.
Objective To explore the value of α-hydroxybutyrate dehydrogenase(α-HBDH)and apolipoprotein B(ApoB)in predicting major adverse cardiovascular events(MACE)occurrence within 3 years after percutaneous coronary intervention(PCI)in acute myocardial infarction(AMI)patients with multivessel disease(MVD).Methods A total of 108 AMI patients with MVD underwent PCI were divided into groups of A(33 cases with MACE)and B(75 cases without MACE)according to 3-year follow-up results.The baseline clinical data of two groups were compared.Multivariate logistic regression was used to analyze the influencing factors for MACE occurrence after PCI in AMI patients with MVD,and ROC curve was drawn to analyze the predictive efficacy of serum levels of α-HBDH and ApoB on MACE occurrence after PCI in AMI patients with MVD.Results Serum levels of α-HBDH and ApoB in group A were higher than those in group B(P<0.05).The increased serum levels of α-HBDH and ApoB were the independent risk factors for MACE occurrence in AMI patients with MVD after PCI(P<0.05).Serum level of α-HBDH or ApoB had better predictive value for MACE occurrence after PCI in AMI patients with MVD(P<0.05).The sensitivity was higher in combination of them than α-HBDH or ApoB alone.Conclusion Serum levels of α-HBDH and ApoB can be used to predict MACE occurrence after PCI in AMI patients with MVD.

α-Hydroxybutyrate dehydrogenaseApolipoprotein BAcute myocardial infarctionMultivessel diseasePercutaneous coronary intervention

蔡蕊、商婷婷、周琳、王翠平、袁伟

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212001 江苏镇江,江苏大学附属医院心血管内科

α羟丁酸脱氢酶 载脂蛋白B 急性心肌梗死 多支血管病变 经皮冠状动脉介入治疗

江苏省卫生健康委员会基金江苏省青年医学重点人才培养基金

H2018004QNRC2016837

2024

江苏医药
江苏省人民医院(南京医科大学第一附属医院)

江苏医药

影响因子:0.707
ISSN:0253-3685
年,卷(期):2024.50(4)
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