Objective To analyze the influencing factors for gastrointestinal adverse reactions in the patients with type 2 diabetes mellitus(T2DM)treated with polyethylene glycol loxenatide.Methods The clinical data of 186 T2DM patients treated with polyethylene glycol loxenatide for the first time on the basis of the original hypoglycemic regimen were retrospectively analyzed.According to whether gastrointestinal adverse reactions occurred within 2 weeks of treatment,the patients were divided into two groups of A(with gastrointestinal adverse reactions,40 cases)and B(without gastrointestinal adverse reactions,146 cases).The general information and differences in biochemical indicators before treatment with polyethylene glycol loxenatide were compared between the two groups.Multivariate logistic regression analysis was used to analyze the influencing factors for the gastrointestinal adverse reactions in T2DM patients treated with polyethylene glycol loxenatide.The ROC curve was plotted to evaluate the predictive value of relevant indicators for gastrointestinal adverse reactions in T2DM patients treated with polyethylene glycol loxenatide.Results The BMI of group A was lower than that of group B(P＜0.01),while the age,T2DM course,and the proportion of the patients with gastrointestinal diseases history were more in group A than those in group B(P＜0.05).Multivariate logistic regression analysis showed that older age and history of gastrointestinal diseases were the independent risk factors for gastrointestinal adverse reactions in T2DM patients treated with polyethylene glycol loxenatide(P＜0.05),while higher level of BMI was an independent protective factor for gastrointestinal adverse reactions in T2DM patients treated with polyethylene glycol loxenatide(P＜0.01).ROC curve analysis showed that the AUC of combined use of BMI,age and history of gastrointestinal diseases in predicting the occurrence of gastrointestinal adverse reactions in T2DM patients treated with polyethylene glycol loxenatide was 0.887[95％CI(0.838-0.936),P＜0.01],and the predictive sensitivity and specificity were 95.0％and 79.5％,respectively.Conclusion BMI,age and history of gastrointestinal diseases are closely related to the occurrence of gastrointestinal adverse reactions in T2DM patients treated with polyethylene glycol loxenatide,in whom combined use of the three factors has a certain predictive value for the occurrence of gastrointestinal adverse reactions.
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