Objective To explore the clinical value of eosinophil percentage in evaluating the efficacy of intravenous glucocorticoid in the patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods One hundred patients with AECOPD were divided into group A(eosinophil percentage＜2％,62 cases)and group B(eosinophil percentage≥2％,38 cases).According to different treatments,groups of A and B were subdivided into groups of A1,A2 and B1,B2.Groups of A2 and B2 were treated with routine bronchodilation symptomatic treatment for 5 days,and groups of A1 and B1 were treated with additional intravenous methylprednisolone 40 mg/d for 5 days.The inflammatory indicators,COPD assessment test(CAT)scores,indicators of pulmonary function and blood gas analysis were compared before and after treatment between the subgroups.The hospital stay and rate of re-hospitalization within 3 months were compared between the subgroups,and the incidence of adverse reactions related to intravenous glucocorticoid was observed as well.Results Compared to before treatment,the inflammation indicators,CAT scores,indicators of pulmonary function and blood gas analysis of groups of A1,A2,B1 and B2 were improved after treatment(P＜0.05),which were improved better in group B1 than those in group B2 after treatment(P＜0.05).The rate of re-hospitalization within 3 months in group A1 was lower than that in group A2(P＜0.05).Compared with group B2,hospital stay in group B1 was shorter and rate of re-hospitalization within 3 months was lower(P＜0.05).The incidence of adverse reactions related to intravenous glucocorticoid in group A1 was similar to that in group B1(P＞0.05).Conclusion The eosinophil percentage can be used as a marker to guide the treatment of intravenous glucocorticoid in AECOPD patients.The AECOPD patients with eosinophil percentage 2％have more sensitive response to intravenous glucocorticoid and better clinical outcomes.
EosinophilGlucocorticoidAcute exacerbation of chronic obstructive pulmonary disease
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