Objective To observe the clinical efficacy of percutaneous electrical acupoint stimulation in assisting total intravenous anesthesia for thyroidectomy.Methods Sixty patients undergoing thyroidectomy under total intravenous anesthesia were randomly divided into two groups with 30 cases each.At 30 minutes before anesthesia induction till the end of operation,percutaneous electrical acupoint stimulation of both sides acupoints of Hegu and Neiguan was performed in group A,percutaneous electrical acupoint stimulation was not performed in group B as control.Both groups received total intravenous anesthesia for induction and maintenance and bispectral index was maintained in 40-60 during surgery.The intraoperative infusion speed of propofol and remifentanil was recorded,the changes of perioperative MAP and HR were compared between two groups,and the incidence of nausea and vomiting within 24 hours after surgery was observed.Results Compared with group B,intraoperative infusion rate of propofol and remifentanil decreased in group A[(182.00 ±6.72)mg/h vs.(245.00±10.64)mg/h and(0.43±0.05)mg/h vs.(0.65±0.06)mg/h](P<0.05).Compared with group B at the same time point,MAP and HR at anesthesia induction were increased,while MAP and HR at surgical incision were decreased in group A(P<0.05).Compared with group B,the times of nausea and vomiting within 24 hours after surgery was reduced in group A[(1.2±0.4)times per hours vs.(3.8±0.6)times per hours](P<0.05).Conclusion Percutaneous electrical acupoint stimulation in assisting total intravenous anesthesia for thyroidectomy has a good effect,can maintain stability of intraoperative circulation,reduce amount of anesthetic drugs and adverse reactions.