摘要
目的 分析IgA肾病(IgAN)患者高尿酸血症发生的影响因素.方法 根据血尿酸水平,将110例IgAN患者分为高尿酸血症组(49例)和正常血尿酸组(61例),比较两组患者临床指标及肾脏病理资料,采用多因素logistic回归分析IgAN患者高尿酸血症发生的影响因素.结果 两组收缩压、舒张压、血尿酸、血清肌酐、三酰甘油、24-h尿蛋白定量、24-h尿蛋白定量分级和Lee氏病理分级比较差异均有统计学意义(P＜0.05).多因素logistic回归分析结果显示,血清肌酐和三酰甘油水平升高是IgAN患者发生高尿酸血症的独立危险因素(P＜0.05).高尿酸血症组患者的血尿酸水平与收缩压、24-h尿蛋白定量、血清肌酐和三酰甘油水平呈正相关(r=0.222、0.317、0.468和0.250,P＜0.05).结论 血尿酸水平可反映IgAN患者临床指标及肾脏病理损伤程度;积极治疗高尿酸血症,控制血压过高,降低血清肌酐、三酰甘油及尿蛋白水平,从而减轻肾脏病理损伤程度,延缓IgAN的进展.
Abstract
Objective To investigate the influencing factors for hyperuricemia in the patients with IgA nephropathy(IgAN).Methods According to the level of blood uric acid,110 patients with IgAN were divided into two groups of A(with hyperuricemia,49 cases)and B(with normal blood uric acid,61 cases).The general clinical indexes and renal pathological data between the two groups were compared.The influencing factors for the occurrence of hyperuricemia in the patients with IgAN was analyzed by multivariate logistic regression.Results There were statistical differences in the SBP,DBP,blood uric acid,SCr,TG,24-hour urinary protein,classification of 24-hour urinary protein and Lee's pathological grade between groups of A and B(P＜0.05).The multivariate logistic regression analysis showed that increased levels of SCr and TG were the independent risk factors for the occurrence of hyperuricemia in the patients with IgAN(P＜0.05).The level of blood uric acid was positively correlated with SBP,24-hour urinary protein,SCr and TG in group A(r=0.222,0.317,0.468 and 0.250,P＜0.05).Conclusion The level of blood uric acid can be used to reflect the degree of clinical data and renal pathological injury in patients with IgAN.Actively treating hyperuricemia,controlling higher blood pressure,decreasing the levels of SCr,TG and urinary protein can alleviate the degree of renal pathological injury and delay the progression of IgAN.
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