Objective To investigate the influencing factors for hyperuricemia in the patients with IgA nephropathy(IgAN).Methods According to the level of blood uric acid,110 patients with IgAN were divided into two groups of A(with hyperuricemia,49 cases)and B(with normal blood uric acid,61 cases).The general clinical indexes and renal pathological data between the two groups were compared.The influencing factors for the occurrence of hyperuricemia in the patients with IgAN was analyzed by multivariate logistic regression.Results There were statistical differences in the SBP,DBP,blood uric acid,SCr,TG,24-hour urinary protein,classification of 24-hour urinary protein and Lee's pathological grade between groups of A and B(P＜0.05).The multivariate logistic regression analysis showed that increased levels of SCr and TG were the independent risk factors for the occurrence of hyperuricemia in the patients with IgAN(P＜0.05).The level of blood uric acid was positively correlated with SBP,24-hour urinary protein,SCr and TG in group A(r=0.222,0.317,0.468 and 0.250,P＜0.05).Conclusion The level of blood uric acid can be used to reflect the degree of clinical data and renal pathological injury in patients with IgAN.Actively treating hyperuricemia,controlling higher blood pressure,decreasing the levels of SCr,TG and urinary protein can alleviate the degree of renal pathological injury and delay the progression of IgAN.
Immunoglobulin A nephropathyBlood uric acidHyperuricemia
NETL
NSTL
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