摘要
目的 探讨短期口服替勃龙对提示宫颈鳞状细胞异常的绝经后女性患者阴道镜下宫颈活检的影响.方法 宫颈液基细胞学检测提示宫颈鳞状细胞异常的绝经后女性患者100例随机均分为A组和C组.A组替勃龙片2.5mg/d 口服14 d后行阴道镜下宫颈活检.C组未口服药直接行阴道镜下宫颈活检.比较两组表层细胞百分比和阴道脱落细胞成熟值、VAS疼痛评分、阴道镜检查充分性、宫颈表面鳞柱交界可见性、转化区类型及阴道出血量.结果 与C组比较,A组表层细胞百分比和阴道脱落细胞成熟值升高,VAS疼痛评分降低,阴道镜检查充分性比例升高且阴道出血量减少(P＜0.05或P＜0.01).两组宫颈表面鳞柱交界可见性和转化区类型比较差异有统计学意义(P＜0.01).结论 短期口服替勃龙可作为提示宫颈鳞状细胞异常的绝经后女性患者阴道镜下宫颈活检的预处理方式.
Abstract
Objective To explore the effect of short-term oral administration of tibolone on colposcopic cervical biopsy in postmenopausal women with abnormal cervical squamous cells.Methods One hundred postmenopausal women with abnormal cervical squamous cell detected by liquid based cytology were randomly divided into two groups of A and C.Colposcopic cervical biopsy was performed in group A after oral administration of tibolone tablet 2.5 mg/d for 14 days.Group C underwent colposcopic cervical biopsy directly without oral administration.The percentage of surface cells,maturity of excalated cells,VAS pain score,adequacy of colposcopy,visibility of squamo-column junction on the surface of the cervix,type of transformation area and amount of vaginal bleeding were compared between the two groups.Results Compared with group C,the percentage of surface cells and maturity value of vaginal excalated cells were increased,VAS pain score was decreased,ratio of adequacy colposcopy was increased,and amount of vaginal bleeding was decreased in group A(P＜0.05 or P＜0.01).There were significant differences in the visibility of squamo-column junction on the surface of the cervix and type of transformation area between the two groups(P＜0.01).Conclusion Short-term oral administration of tibolone can be used as a preconditioning method for colposcopic cervical biopsy in postmenopausal women with abnormal cervical squamous cells.
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