D-二聚体和血小板计数预测过敏性紫癜性肾炎的价值
Value of D-dimer and platelet count in predicting Henoch-Sch?nlein purpura nephritis
朱琨 1季伟 1田凌峰 1陈国玉1
作者信息
- 1. 224005 江苏盐城,南京大学医学院附属盐城第一医院(盐城市第一人民医院)儿科
- 折叠
摘要
目的 探讨D-二聚体和血小板计数预测过敏性紫癜性肾炎(HSPN)的价值.方法 按照有无肾损害将68例过敏性紫癜(HSP)患儿分为HSP无肾炎组(A组,38例)和HSPN组(B组,30例).分析D-二聚体和血小板计数预测HSPN的价值.结果 与A组比较,B组D-二聚体和血小板计数升高(P＜0.05).单因素logistic回归分析显示,D-二聚体和血小板计数升高是影响HSPN的危险因素(P＜0.05);ROC曲线分析显示,D-二聚体和血小板计数预测HSPN的曲线下面积分别为0.903和0.846(P＜0.05),其预测HSPN的灵敏度与特异度均高于80％.结论 HSPN患儿具有更高的D-二聚体和血小板计数,两者升高是影响HSPN的危险因素,提示临床上对D-二聚体或血小板计数明显升高的HSP患儿应及时治疗,密切观察,以尽量减少HSPN的发生.
Abstract
Objective To explore the value of D-dimer and platelet count in predicting Henoch-Schönlein purpura nephritis(HSPN).Methods A total of 68 children diagnosed with Henoch-Schönlein purpura(HSP)were divided into two groups of A(without nephritis,38 cases)and B(with HSPN,30 cases).The value of D-dimer and platelet count in predicting HSPN was analyzed.Results The levels of D-dimer and platelet count in group B were significantly higher than those in group A(P＜0.05).Univariate logistic regression analysis showed that higher D-dimer and platelet count were the risk factors for HSPN(P＜0.05).The AUC values for D-dimer and platelet count were 0.903 and 0.846,respectively and the sensitivity and specificity in predicting HSPN were over 80％.Conclusion The children with HSPN have higher D-dimer and platelet count.The increase of both D-dimer and platelet count are the risk factors for HSPN,suggesting that HSP children with increased D-dimer and platelet count should be treated promptly and observed closely to minimize the occurrence of HSPN.
关键词
D-二聚体/血小板计数/过敏性紫癜/过敏性紫癜性肾炎Key words
D-dimer/Platelet count/Henoch-Schönlein purpura/Henoch-Schönlein purpura nephritis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据