Objective To analyze the influencing factors for the mortality of the premature infants.Methods The clinical data of 34 dead premature infants(group A),34 alive premature infants(group B)and their mothers were retrospectively analyzed.The influencing factors for the mortality of the premature infants were analyzed by multivariate logistic regression.Results The proportions of male premature infants,neonatal asphyxia,multiple pregnancy and mothers with gynecological diseases were higher,while the RBC,Plt and hospital stays of the premature infants and the proportion of mothers with regular prenatal examination were lower in group A than those in group B(P<0.05).The multivariate logistic regression analysis showed that the male,neonatal asphyxia and multiple pregnancy were the independent risk factors,while the increased Plt was the independent protective factor for the mortality of the premature infants(P<0.01).Conclusion To reduce the mortality of the premature infants,more attention should be paid to the premature infants with high risk factors,such as male,neonatal asphyxia,multiple pregnancy and decreased Plt.