Clinical significance of NLR and PLR in children with infectious mononucleosis
Objective To investigate the changes and clinical significance of neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)in the children with infectious mononucleosis(IM).Methods According to the liver function,139 children with IM(group A)were divided into two groups of A1(with abnormal liver function,72 cases)and A2(with normal liver function,67 cases).Another 66 healthy children were taken as the controls(group C).The blood routine and blood biochemistry examinations were analyzed by fully automatic hematology analyzer and fully automatic biochemical analyzer,respectively.Then NLR and PLR were calculated.The lymphocyte subsets were detected by flow cytometry,and the ratio of CD4+to CD8+was calculated.Results Compared with group C,the WBC,lymphocyte count,proportions of CD3+and CD3+CD8+and levels of IgG,IgA and IgM were increased(P＜0.05),while the Plt,NLR,PLR,ratio of CD4+to CD8+and the proportions of CD3+CD4+,CD3-CD19+,CD3-CD16+CD56+and CD19+CD23+were decreased in group A(P＜0.05).Compared with group A2,the lymphocyte count,proportion of CD3+CD8+and levels of IgG,IgA and IgM were increased(P＜0.05),whereas the neutrophil count,Plt,NLR,PLR,ratio of CD4+to CD8+and proportions of CD3+CD4+and CD3-CD19+were decreased in group A1(P＜0.05).NLR was positively correlated with neutrophil count,Plt,proportion of CD3-CD19+and ratio of CD4+to CD8+(P＜0.05),but was negatively correlated with WBC,lymphocyte count and proportions of CD3+and CD3+CD8+(P＜0.05).PLR was positively correlated with Plt,ratio of CD4+to CD8+and proportions of CD3+CD4+and CD3-CD19+(P＜0.05),but was negatively correlated with WBC,lymphocyte count,proportion of CD3+CD8+and levels of IgM and IgG(P＜0.05).Conclusion NLR and PLR are associated with liver function impairment and immune disorders in the children with IM,and can be used as a clinical aid in the assessment of disease severity in the children with IM.
Infectious mononucleosisThe ratio of neutrophil to lymphocyteThe ratio of platelet to lymphocyteChildren
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