Objective To explore the relationship between fibrinogen(Fib),PR interval and lower extremity arteriosclerosis obliterans(ASO)in elderly patients with type 2 diabetes mellitus(T2DM).Methods The relevant clinical data including laboratory indicators and PR interval were collected in 106 elderly T2DM patients with lower extremity ASO(group ASO)and 122 elderly T2DM patients without lower extremity ASO(group C).Logistic regression analysis was used to analyze the influencing factors for lower extremity ASO in elderly T2DM patients,and ROC curve was used to evaluate the value of Fib and PR interval in diagnosing lower extremity ASO in elderly T2DM patients.Results Compared with group C,the patients of group ASO were older in age,had longer duration of T2DM and wider PR interval,and were with higher proportions of male,smoking history,coronary heart disease and diabetic peripheral neuropathy(P＜0.05).The levels of albumin and HDL-C were lower,the levels of Fib,uric acid,SCr,C-peptide and Plt and the ratio of urinary albumin to urinary creatinine were higher in group ASO than those in group C(P＜0.05).Older age,male,diabetic peripheral neuropathy,higher Fib and longer PR interval were the independent risk factors for lower extremity ASO in elderly T2DM patients(P＜0.05).The AUC values of Fib and PR interval in diagnosing lower extremity ASO of elderly patients were 0.760 and 0.652,respectively.When the best cut-off values of Fib and PR interval were 3.68 g/L and 170 ms,the sensitivity were 67.4％and 50.6％,and the specificity were 78.7％and 72.1％,respectively.Conclusion The Fib and PR interval are the independent influencing factors for lower extremity ASO in elderly T2DM patients,which have a certain value in diagnosing lower extremity ASO.
Type 2 diabetes mellitusLower extremity arteriosclerosis obliteransFibrinogenPR intervalGeriatrics
NETL
NSTL
万方数据
