摘要
目的 探讨维生素C联合碳酸氢钠中和卢戈氏碘的安全性和有效性.方法 行普通胃镜检查的受试者156例,随机分为三组,每组52例.常规内镜检查后,对食管喷洒2％卢戈氏碘液10mL.碘染结束后,硫代硫酸钠(STS)组喷洒5％STS溶液20 mL,维生素C组喷洒2％维生素C溶液20 mL,维生素C+碳酸氢钠组喷洒2％维生素C及1％碳酸氢钠混合液20 mL.分别于碘染后5min、30min、24h统计不适症状发生情况,评估食管黏膜及胃黏液池的褪色效果.结果 维生素C+碳酸氢钠组碘染后24 h内不良反应总发生率低于STS组(P＜0.05).碘染后5 min,维生素C+碳酸氢钠组不适症状评分低于STS组(P＜0.05).三组食管黏膜、胃黏液池褪色效果评分比较差异均无统计学意义(P＞0.05).结论 维生素C联合碳酸氢钠可用于中和卢戈氏碘,不良反应发生率低,且不影响褪色效果.
Abstract
Objective To observe the safety and efficacy of vitamin C combined with sodium bicarbonate for neutralizing Lugol's iodine.Methods A total of 156 patients undergoing general gastroscopy were divided into three groups with 52 cases each.After routine endoscopy,2％Lugol's iodine solution 10 mL was sprayed into the esophagus for iodine staining.After iodine staining,group A was sprayed with 5％sodium thiosulfate solution 20 mL,group B was sprayed with 2％vitamin C solution 20 mL and group C was sprayed with 2％vitamin C and 1％sodium bicarbonate mixture 20 mL.The incidences of discomfort symptoms were evaluated at 5 minutes,30 minutes and 24 hours after iodine staining.The fading effects of esophageal mucosa and gastric mucous pool were evaluated.Results The incidence of total adverse reactions within 24 hours after iodine staining was lower in group C than that in group A(P＜0.05).The discomfort symptom score of group C was lower than that of group A at 5 minutes after iodine staining(P＜0.05).There were no significant differences in the fading effect scores of esophageal mucosa and gastric mucous pool among the three groups(P＞0.05).Conclusion Vitamin C combined with sodium bicarbonate can be used to neutralize Lugol's iodine with low incidence of adverse reactions and without influence on the fading effect.
基金项目
徐州市科技项目(KC22095)
徐州市医学领军人才培养项目(XWRCHT20210025)
NETL
NSTL
万方数据