Relationship of serum RasGRP1 with inflammatory factor levels and symptom severity in patients with first-episode schizophrenia
Objective To explore the relationship of serum Ras guanine nucleotide releasing protein 1(RasGRP1)with interleukin 1β(IL-1β),interleukin 6(IL-6),tumor necrosis factor-α(TNF-α)levels and symptom severity in the patients with first-episode schizophrenia(FES).Methods Forty-eight FES patients(FES group)and 30 healthy individuals(control group)were selected.Serum levels of RasGRP1,IL-1β,IL-6 and TNF-α were detected using enzyme-linked immunosorbent assay.The severity of psychiatric symptoms was assessed using the positive and negative syndrome scale(PANSS).ROC curves were drawn to analyze the diagnostic value of serum indicators for FES.Pearson correlation analysis was used to analyze the correlation of serum RasGRP1 level with IL-1β,IL-6,TNF-α levels,as well as PANSS scores in the patients with FES.Results Serum levels of RasGRP1,IL-1β,IL-6 and TNF-α in FES group were higher than those in control group(P＜0.05).The ROC curve analysis showed that the AUC of RasGRP1 for the diagnosis of FES was higher than that of IL-1β,IL-6 and TNF-α(0.788 vs.0.614,0.695 and 0.547)(P＜0.05).Serum RasGRP1 level in FES patients was positively correlated with IL-1β,IL-6 and TNF-α(r=0.587,0.701 and 0.412,P＜0.05).Serum RasGRP1 level in FES patients was positively correlated with PANSS positive symptom score,negative symptom score and total score(r=0.589,0.673 and 0.704,P＜0.05).Conclusion Serum RasGRP1 level in FES patients is elevated,which is positively correlated with serum levels of IL-1β,IL-6 and TNF-α and associated with the severity of psychiatric symptoms.
First-episode schizophreniaRas guanine nucleotide releasing protein 1Inflammatory factorsInflammatory damagePsychiatric symptoms
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