Diagnostic value of blood biomarkers in senile frailty syndrome
Objective To explore the diagnostic value of blood biomarkers in senile frailty syndrome.Methods Ninety-four elderly patients were divided into two groups of A(with senile frailty syndrome,FRAIL scale ≥3 items,47 cases)and B(without senile frailty syndrome,FRAIL scale＜3 items,47 cases).The relevant data including blood routine,biochemistry,N-terminal B-type natriuretic peptide precursor(NT-proBNP)and estimated glomerular filtration rate(eGFR)were collected.The risk factors for senile frailty syndrome were analyzed with univariate and multivariate logistic regression analysis.ROC curve was drawn to evaluate the diagnostic value of each variable for senile frailty syndrome.Results The levels of NT-proBNP,neutrophil count,neutrophil proportion in group A were higher than those in group B,while albumin,Hb,TC and eGFR were lower in group A than those in group B(P＜0.05).Univariate logistic regression analysis showed that the increases of NT-proBNP and neutrophil proportion and the decreases of albumin,Hb,TC and eGFR were the risk factors for senile frailty syndrome(P＜0.05).The AUC of NT-proBNP in the diagnosis of senile frailty syndrome was higher than that of eGFR,albumin,TC and neutrophil proportion(P＜0.05).Multivariate logistic regression analysis showed that the increase of NT-proBNP and the decrease of Hb were the independent risk factors for senile frailty syndrome(P＜0.05).ROC analysis results showed that the AUC of the combined detection of NT-proBNP and Hb for the diagnosis of senile frailty syndrome was 0.901[95％CI(0.822-0.953),P＜0.01]with the sensitivity and specificity of 91.5％and 76.6％.Conclusion The pathogenesis of senile frailty syndrome is complex.Different blood biomarkers reflect different aspect of senile frailty syndrome.Combined detection of NT-proBNP and Hb has higher diagnostic value for senile frailty syndrome.
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