Therapeutic efficacy of intra-articular injection of TNF-α antagonist in the treatment of rheumatoid arthritis
Objective To observe the efficacy of intra-articular injection of TNF-α antagonist in the patients with rheumatoid arthritis(RA).Methods A total of 79 RA patients were divided into two groups.The patients in group A(49 cases)were treated with intra-articular injection of 25 mg TNF-α antagonist once every two weeks,3 to 5 times consecutively.The patients in group C(30 cases)were treated with intra-articular injection of 1 mL betamethasone once.The changes of joint swelling and pain were evaluated at the time points of the 2th,4th,8th,12th and 24th week of the tratment.The recurrence of arthritis and the occurrence of treatment-related adverse reactions were recorded in two groups within 6 months of follow-up.Results Compared with before treatment,the synovial hypertrophy was significantly improved from the 8th week in group A and from the 4th week in group C(P＜0.05),the synovial effusion of two groups was significantly reduced from the 2th week(P＜0.05),power Doppler signal was significantly decreased in both groups from the 12th week(P＜0.05),and the VAS pain scores of both groups were significantly decreased from the 2th week(P＜0.05).There were no significant differences in ESR and CRP levels before and after treatment in two groups(P＞0.05).The arthritis recurrence rate was lower in group A than that in group C(24.49％vs.43.33％).No obvious treatment-related adverse reactions were observed in the two groups.Conclusion Intra-articular injection of TNF-α antagonist is safe and effective in the treatment of RA patients.
NETL
NSTL
万方数据
