The value of serum Ⅰ-FABP and CBG in predicting the need for surgical treatment of neonatal necrotizing enterocolitis
Objective To explore the predictive value of serum intestinal fatty acid binding protein(Ⅰ-FABP)and β-glucosidase(CBG)in the need for surgical treatment of neonatal necrotizing enterocolitis(NEC).Methods A total of 93 newborns diagnosed with NEC were divided into two groups of A(underwent surgical treatment,27 cases)and B(underwent non-surgical treatment,66 cases).The general information and serum Ⅰ-FABP and CBG levels at the time of NEC diagnosis were compared between the two groups.Multivariate logistic regression analysis was used to investigate the independent influencing factors in the need of surgical treatment in NEC patients.Results Serum levels of Ⅰ-FABP and CBG in group A were higher than those in group B(P＜0.05).The results of multivariate logistic regression analysis showed that the elevated levels of Ⅰ-FABP and CBG at the time of NEC diagnosis were the independent risk factors for the need of surgical treatment in NEC patients(P＜0.05).The AUC of Ⅰ-FABP combined with CBG detection in predicting NEC patients requiring surgical treatment was 0.941[95％CI(0.888-0.993),P＜0.01],with corresponding predictive sensitivity and specificity of 85.0％and 94.0％,respectively.Conclusion Serum levels of Ⅰ-FABP and CBG at the time of neonatal NEC diagnosis can help to predict the need for surgical treatment in the early stage.
NETL
NSTL
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