Effect of subanesthetic dose of S-ketamine pretreatment on postoperative cognitive function in elderly patients undergoing laparoscopic radical resection of gastrointestinal tumor
Objective To explore the effect of subanesthetic dose of S-ketamine pretreatment on postoperative cognitive function in elderly patients undergoing laparoscopic radical resection of gastrointestinal tumor.Methods A total of 100 patients undergoing laparoscopic radical resection of gastrointestinal tumor under general anesthesia were divided into two groups with 50 cases each.Ten minutes before anesthesia induction,group S was given intravenous injection of S-ketamine 0.2 mg/kg and group C was given equal volume of normal saline.Serum levels of neuron specific enolase(NSE)and S-100β were measured before administration(T0),one hour after skin incision(T1),3 hours after surgery(T2)and 24 hours after surgery(T3).The Montreal Cognitive Assessment(MoCA)scale was used to assess cognitive function,the incidence of postoperative cognitive dysfunction(POCD)was evaluated 7 days after surgery.Results Serum levels of NSE and S-100β of two groups were higher at T1-T3 than those at T0(P＜0.05).Compared with group C,serum levels of NSE and S-100β in group S were decreased at T1-T3(P＜0.05).The MoCA scores of two groups were lower in the 1st,3rd and 7th day after surgery than those before(P＜0.05),which were higher in group S than those in group C(P＜0.05).The incidence of POCD was lower in group S than that in group C 7 days after surgery(4％vs.16％)(P＜0.05).Conclusion Subanesthetic dose of S-ketamine pretreatment may reduce the occurrence of POCD in elderly patients undergoing laparoscopic radical resection of gastrointestinal tumor.
S-ketamineRadical resection of gastrointestinal tumorCognitive functionGeriatrics
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