Objective To analyze the influencing factors and outcomes of differentiation syndrome(DS)in acute promyelocytic leukemia(APL)patients.Methods The clinical data of 82 newly diagnosed APL patients were retrospectively analyzed,who were divided into two groups of A(with DS,40 cases)and B(without DS,42 cases)according to whether DS occurred.The clinical indexes were compared between the two groups,and the influencing factors and outcomes of DS were analyzed.Results Peak white blood cell count during induction therapy and the proportion of the patients with high risk of prognosis stratification and bleeding before induction therapy were higher in group A than those in group B(P＜0.05).Univariate logistic regression analysis showed that bleeding before induction therapy,higher risk of prognosis stratification and peak white blood cell count during induction therapy were the risk factors for DS(P＜0.05 or P＜0.01).Multivariate logistic regression analysis showed that higher peak white blood cell count during induction therapy was an independent risk factor for DS(P＜0.01).Among the 40 patients in group A,one patient died after treatment,and the other 39 patients were cured by the treatment with steroids or reducing arsenic trioxide and/or all trans retinoic acid.The cure time of DS was 8(5,12)days.Conclusion Higher peak white blood cell count during induction therapy is an independent risk factor for DS in APL patients.Taking the measures timely can effectively treat DS.
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