Correlation analysis between nailfold microcirculation and disease activity in patients with dermatomyositis
Objective To analyze the correlation between nailfold microcirculation and disease activity in the patients with dermatomyositis.Methods The clinical data of 20 patients with dermatomyositis(group A)and 20 healthy people(group B)were collected.The nailfold microcirculation in group A was detected by nailfold video capillary scope and disease activity was accessed by visual simulation assessment tool for myositis activity.The correlation between nail fold microcirculation and disease activity was evaluated by Pearson correlation analysis.Results Compared to group B,the number of capillary loops was less,the top diameter of capillary loops was larger,and the proportions of microbleeds,ESR and CRP were higher in group A(P＜0.05).The total disease activity was(4.48±1.18)points,the muscle disease activity was(4.62±1.24)points,and the lung disease activity was(2.37±0.90)points in group A.The number of capillary loops was negatively correlated with muscle disease activity and lung disease activity(r=-0.907 and-0.500,P＜0.05).The top diameter of capillary loops was positively correlated with total disease activity,muscle disease activity and lung disease activity(r=0.462,0.644 and 0.523,P＜0.05).Conclusion Nailfold microcirculation is closely correlated with disease activity in the patients with dermatomyositis.
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