Effects of peritoneal spraying of Pseudomonas aeruginosa-mannose sensitive hemagglutinin on perioperative immune levels of patients with colorectal cancer
Objective To investigate the effects of peritoneal spraying of Pseudomonas aeruginosa(PA)-mannose sensitive hemagglutinin(MSHA)on the perioperative immune levels of patients with colorectal cancer.Methods A total of 61 patients with colorectal cancer underwent surgical treatment.Before abdomen closed,PA-MSHA 15 mL was sprayed peritoneally in 31 patients(group A)or normal saline 15 mL was sprayed peritoneally in 30 patients(group C).Peripheral blood lymphocytes and monocytes were compared between the two groups before surgery and on the 3rd day after surgery.Serum immune-related indicators were compared between the two groups before surgery and on the 5th day after surgery.Results On the 3rd day after surgery,lymphocyte count and lymphocyte percentage were decreased in groups of A and C(P＜0.01).On the 5th day after surgery,serum IL-6 level was higher in groups of A and C(P＜0.01)The monocyte count on the 3rd day after surgery was decreased in group C,and serum levels of IL-2 and TNF-α on the 5th day after surgery were increased in group A(P＜0.05).Compared with group C,lymphocyte count on the 3rd day after surgery was higher in group A(P＜0.05).Compared with group C,serum levels of IL-2,IL-6 and TNF-α on the 5th day after surgery were increased in group A(P＜0.05 or P＜0.01).The incidences of adverse reactions from postoperative to discharge of two groups were similar(P＞0.05).Conclusion In the patients with colorectal cancer,peritoneal spraying of PA-MSHA can effectively improve perioperative immune levels.
Pseudomonas aeruginosaMannose sensitive hemagglutininPeritoneal sprayingColorectal cancer
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