Objective To analyze the correlation of serum uric acid(SUA)level and the risk for the occurrence of obstructive sleep apnea hypopnea syndrome(OSAHS)in the patients with type 2 diabetes mellitus(T2DM).Methods Relevant clinical data of T2DM inpatients were retrospectively analyzed.The SUA level third quartile was defined as high SUA and apnea hypopnea index(AHI)≥5 was defined as OSAHS.Of 200 T2DM patients,110 cases were with OSAHS(group A)and 90 cases were without OSAHS(group B).The SUA level of the two groups was compared,and the correlation between SUA level and OSAHS parameters was analyzed,and the correlation between SUA level and the risk for OSAHS was analyzed,as well as the correlation between SUA level and risk for OSAHS under different metabolic states was analyzed.Results SUA was significantly higher in group A than that in group B(P＜0.05).SUA was positively correlated with AHI and oxygen desaturation index and negetively correlated with average value of blood oxygen saturation and minimum blood oxygen saturation(P＜0.05).For each SD deviation of SUA,the risk of OSAHS increased 0.5 time[OR=1.50,95％CI(1.06-2.18)].Compared to T2DM patients with low levels of SUA,T2DM patients with high levels of SUA had a 1.10 times increased risk for OSAHS[OR=2.10,95％CI(1.03-4.30)].In T2DM patients with metabolic syndrome,the risk for OSAHS increased 1.96 times[OR=2.96,95％CI(1.48-5.91)].Conclusion The SUA level in T2DM patients is strongly associated with the risk for the occurrence of OSAHS.The T2DM patients with metabolic syndrome have a significantly increased risk of OSAHS.
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